Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 18 Researches
8.4
USERS' SCORE
Good
Based on 281 Reviews
8.2
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Nattokinase (from fibrinase enzymes)
2,000 FU**
†
Top Medical Research Studies
9
Nattokinase shows strong clot-busting activity
We explored the effectiveness of nattokinase, a natural enzyme known for its role in breaking down blood clots, by studying its production and activity in a lab setting. Nattokinase was extracted from Bacillus subtilis, and we introduced this gene into E. coli bacteria to produce the enzyme at high levels.
Through our process, we purified the active recombinant nattokinase and tested its ability to dissolve blood clots. Our results were promising; the enzyme exhibited a fibrinolytic activity of 58FU/mg, which is notably five times more effective than the currently used drug, orokinase.
We optimized the conditions for producing nattokinase, including factors like temperature and nutrient concentrations, resulting in an impressive yield of 1805.50 mg/L. This improved production method paves the way for scaling up nattokinase's use in treating cardiovascular diseases related to blood clots. The findings emphasize nattokinase's potential as an effective thrombolytic agent.
Through our process, we purified the active recombinant nattokinase and tested its ability to dissolve blood clots. Our results were promising; the enzyme exhibited a fibrinolytic activity of 58FU/mg, which is notably five times more effective than the currently used drug, orokinase.
We optimized the conditions for producing nattokinase, including factors like temperature and nutrient concentrations, resulting in an impressive yield of 1805.50 mg/L. This improved production method paves the way for scaling up nattokinase's use in treating cardiovascular diseases related to blood clots. The findings emphasize nattokinase's potential as an effective thrombolytic agent.
Read More
9
We explored the fascinating impact of nattokinase, a natural enzyme known for its blood-thinning properties, particularly its effect on blood clots. In our investigation, we examined how nattokinase interacts with thrombin, a key protein involved in the clotting process, and identified this enzyme as a significant substrate for nattokinase.
By employing a stepwise computational strategy, we modeled the interactions between nattokinase and thrombin to pinpoint specific cleavage sites. This innovative approach allowed us to validate our predictions through mass spectrometry and functional assays, solidifying our understanding of how nattokinase works at a molecular level.
Our findings reveal that nattokinase might play a vital role in breaking the cycle of inflammation and thrombosis by targeting thrombin, thus enhancing its therapeutic potential for cardiovascular health. Overall, this study sheds light on the crucial interactions between these proteins and underscores the importance of nattokinase in managing blood clot dynamics.
By employing a stepwise computational strategy, we modeled the interactions between nattokinase and thrombin to pinpoint specific cleavage sites. This innovative approach allowed us to validate our predictions through mass spectrometry and functional assays, solidifying our understanding of how nattokinase works at a molecular level.
Our findings reveal that nattokinase might play a vital role in breaking the cycle of inflammation and thrombosis by targeting thrombin, thus enhancing its therapeutic potential for cardiovascular health. Overall, this study sheds light on the crucial interactions between these proteins and underscores the importance of nattokinase in managing blood clot dynamics.
Read More
9
We aimed to explore how nattokinase, a key enzyme in natto—a traditional Japanese fermented soy product—affects blood clots. Our focus was on a newly isolated strain from Indonesian natto, named G8, which showed promising fibrinolytic activity, meaning its ability to dissolve blood clots.
Through various fibrinolytic assays, we discovered that both nattokinase and G8 could effectively dissolve clots from whole blood and euglobulin, indicating their potential in managing vascular obstructive diseases. A closer look at G8 revealed that it can directly break down fibrin, which is crucial in clot formation.
Interestingly, the crude extract of G8 demonstrated six distinct bands of activity on zymography, with the most potent activity found at a molecular weight of 20.0 kDa. This suggests that G8 contains a variety of fibrinolytic enzymes, potentially including nattokinase and others that support its clot-dissolving abilities. In summary, we observed that G8 exhibits strong fibrinolytic properties, supported by multiple enzymes working together to aid in clot dissolution.
Through various fibrinolytic assays, we discovered that both nattokinase and G8 could effectively dissolve clots from whole blood and euglobulin, indicating their potential in managing vascular obstructive diseases. A closer look at G8 revealed that it can directly break down fibrin, which is crucial in clot formation.
Interestingly, the crude extract of G8 demonstrated six distinct bands of activity on zymography, with the most potent activity found at a molecular weight of 20.0 kDa. This suggests that G8 contains a variety of fibrinolytic enzymes, potentially including nattokinase and others that support its clot-dissolving abilities. In summary, we observed that G8 exhibits strong fibrinolytic properties, supported by multiple enzymes working together to aid in clot dissolution.
Read More
Most Useful Reviews
9
Improved blood circulation
895 people found this helpful
I take nattokinase for blood thinning. Blood tests showed aggregation of erythrocytes and platelets, but after a month of use, there was significant improvement. I experienced heaviness in my head and legs, which gradually subsided. All tests returned to normal.
Read More
9
Significant improvement
584 people found this helpful
I’ve seen great results with my husband, who has a blood clotting disorder and was on Coumadin for life. It had many unpleasant side effects. We sought an alternative, and this supplement, recommended 10 months ago, has made a remarkable difference. He feels much better on Nattokinase, is off Coumadin (without his doctor's blessing), and has seen improvements in cholesterol and blood pressure. His recent eye exam showed no worsening, which has never happened before. We're hopeful for further benefits.
Read More
9
Reduced blood thickness
394 people found this helpful
My father had thick blood due to high cholesterol and developed diabetes post-Covid. After trying various blood thinning medications, I ordered him this highly rated nattokinase. Within a month, his blood became much thinner and his blood pressure began to normalise. He is very pleased with the results.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 18 Researches
8.4
- All Researches
9
We explored the impact of nattokinase, a natural enzyme known for breaking down blood clots, particularly in the context of acute myocardial infarction (MI), a serious heart condition often caused by these clots. The study investigated a special formulation combining nattokinase with a manganese oxide nanozyme, designed to enhance its effectiveness and stability.
Through tail vein injections into a mouse model, the combination of manganese oxide and nattokinase showed promising results. We observed that this innovative treatment not only helped dissolve clots but also countered oxidative stress—an issue that often exacerbates heart damage. The results indicated significant improvements in restoring blood flow and reducing heart injury.
Overall, our findings suggest that this nattokinase-loaded nanozyme could represent a valuable new tool in treating acute MI, potentially paving the way for better therapeutic strategies in the clinical setting.
Through tail vein injections into a mouse model, the combination of manganese oxide and nattokinase showed promising results. We observed that this innovative treatment not only helped dissolve clots but also countered oxidative stress—an issue that often exacerbates heart damage. The results indicated significant improvements in restoring blood flow and reducing heart injury.
Overall, our findings suggest that this nattokinase-loaded nanozyme could represent a valuable new tool in treating acute MI, potentially paving the way for better therapeutic strategies in the clinical setting.
Read More
9
We explored the effectiveness of a novel treatment combining nattokinase with magnetic vortex nanorobots for tackling blood clots. The study cleverly used these tiny robots, which are about 70 nanometers in size, powered by dual-frequency magnetic fields to improve drug delivery and enhance the effects of nattokinase.
By assembling into chain-like formations, these nanorobots can navigate through microvascular systems and directly target clots, creating mechanical forces to disrupt them efficiently. The combination of a low-frequency rotating field and a high-frequency alternating field helped not only to penetrate the thrombus but also to release nattokinase effectively.
Our findings revealed that this innovative approach, termed dual frequency-regulated magnetothrombolysis, achieved an impressive vasculature recanalization rate of 81.0% in thrombotic mice. This suggests that enhancing the therapeutic qualities of nattokinase with advanced nanotechnology represents a promising pathway for resolving blood clots more effectively.
By assembling into chain-like formations, these nanorobots can navigate through microvascular systems and directly target clots, creating mechanical forces to disrupt them efficiently. The combination of a low-frequency rotating field and a high-frequency alternating field helped not only to penetrate the thrombus but also to release nattokinase effectively.
Our findings revealed that this innovative approach, termed dual frequency-regulated magnetothrombolysis, achieved an impressive vasculature recanalization rate of 81.0% in thrombotic mice. This suggests that enhancing the therapeutic qualities of nattokinase with advanced nanotechnology represents a promising pathway for resolving blood clots more effectively.
Read More
9
We explored how a combination of nattokinase (NK) and heparin (HP) can tackle cancer-related thrombosis (CAT), a common issue in cancer patients that can worsen their condition and quality of life. In our approach, we developed an electrostatic complex of these two agents to mitigate the toxicity typically associated with intravenous NK administration.
Our findings were quite promising. We observed that this NK-HP complex not only addressed the toxicity of NK but also demonstrated strong abilities to break down blood clots. The combination therapy was able to prevent new thrombosis from forming, significantly aiding its use in advanced tumors. Additionally, we found that administering NK-HP alongside specially formulated doxorubicin liposomes enhanced the treatment's effectiveness. This improvement was attributed to reduced fibrin levels in tumors and increased breakdown products, pointing to successful clot dissolution.
Importantly, our work highlights a potential breakthrough in managing CAT in cancer treatment, suggesting that our NK-HP method could be an effective strategy for improving outcomes in patients facing advanced tumors.
Our findings were quite promising. We observed that this NK-HP complex not only addressed the toxicity of NK but also demonstrated strong abilities to break down blood clots. The combination therapy was able to prevent new thrombosis from forming, significantly aiding its use in advanced tumors. Additionally, we found that administering NK-HP alongside specially formulated doxorubicin liposomes enhanced the treatment's effectiveness. This improvement was attributed to reduced fibrin levels in tumors and increased breakdown products, pointing to successful clot dissolution.
Importantly, our work highlights a potential breakthrough in managing CAT in cancer treatment, suggesting that our NK-HP method could be an effective strategy for improving outcomes in patients facing advanced tumors.
Read More
9
We explored the effectiveness of nattokinase in helping dissolve blood clots while also addressing inflammation. The study successfully created amphiphilic block polymer-based nanovesicles that release both the anti-inflammatory drug indomethacin and nattokinase specifically at sites where reactive oxygen species (ROS) are plentiful—like inflamed or thrombotic tissues.
The combination of these drugs is significant; however, evaluating nattokinase's isolated effect is complex due to its combined use with indomethacin. The dual-action nanovesicles showed promising results in a mouse model of thrombosis, enhancing treatment outcomes by quickening the release of both drugs in response to inflammatory conditions.
Despite the potential of nattokinase, the findings indicate that its effect cannot be isolated from that of indomethacin, making it difficult to assess its individual contribution to thrombolytic success.
The combination of these drugs is significant; however, evaluating nattokinase's isolated effect is complex due to its combined use with indomethacin. The dual-action nanovesicles showed promising results in a mouse model of thrombosis, enhancing treatment outcomes by quickening the release of both drugs in response to inflammatory conditions.
Despite the potential of nattokinase, the findings indicate that its effect cannot be isolated from that of indomethacin, making it difficult to assess its individual contribution to thrombolytic success.
Read More
9
Nattokinase shows strong clot-busting activity
We explored the effectiveness of nattokinase, a natural enzyme known for its role in breaking down blood clots, by studying its production and activity in a lab setting. Nattokinase was extracted from Bacillus subtilis, and we introduced this gene into E. coli bacteria to produce the enzyme at high levels.
Through our process, we purified the active recombinant nattokinase and tested its ability to dissolve blood clots. Our results were promising; the enzyme exhibited a fibrinolytic activity of 58FU/mg, which is notably five times more effective than the currently used drug, orokinase.
We optimized the conditions for producing nattokinase, including factors like temperature and nutrient concentrations, resulting in an impressive yield of 1805.50 mg/L. This improved production method paves the way for scaling up nattokinase's use in treating cardiovascular diseases related to blood clots. The findings emphasize nattokinase's potential as an effective thrombolytic agent.
Through our process, we purified the active recombinant nattokinase and tested its ability to dissolve blood clots. Our results were promising; the enzyme exhibited a fibrinolytic activity of 58FU/mg, which is notably five times more effective than the currently used drug, orokinase.
We optimized the conditions for producing nattokinase, including factors like temperature and nutrient concentrations, resulting in an impressive yield of 1805.50 mg/L. This improved production method paves the way for scaling up nattokinase's use in treating cardiovascular diseases related to blood clots. The findings emphasize nattokinase's potential as an effective thrombolytic agent.
Read More
User Reviews
USERS' SCORE
Good
Based on 281 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved blood circulation
895 people found this helpful
I take nattokinase for blood thinning. Blood tests showed aggregation of erythrocytes and platelets, but after a month of use, there was significant improvement. I experienced heaviness in my head and legs, which gradually subsided. All tests returned to normal.
Read More
9
Significant improvement
584 people found this helpful
I’ve seen great results with my husband, who has a blood clotting disorder and was on Coumadin for life. It had many unpleasant side effects. We sought an alternative, and this supplement, recommended 10 months ago, has made a remarkable difference. He feels much better on Nattokinase, is off Coumadin (without his doctor's blessing), and has seen improvements in cholesterol and blood pressure. His recent eye exam showed no worsening, which has never happened before. We're hopeful for further benefits.
Read More
9
Reduced blood thickness
394 people found this helpful
My father had thick blood due to high cholesterol and developed diabetes post-Covid. After trying various blood thinning medications, I ordered him this highly rated nattokinase. Within a month, his blood became much thinner and his blood pressure began to normalise. He is very pleased with the results.
Read More
9
Effective DVT prevention
388 people found this helpful
Nattokinase has been shown to help dissolve fibrin that can linger in blood vessels after DVT or blood clots. I rely on it for my health, having suffered multiple DVTs over the years. It's vital for me to prevent and dissolve blood clots to enhance my quality of life. Many professionals are surprised at the improvement in my leg's appearance, despite my conditions.
Read More
9
Reduced heart attack risk
293 people found this helpful
I discovered nattokinase when my father faced heart issues after a heart attack. After consulting his physician, we opted for this natural remedy. Over a year, his blood circulation improved without any further heart episodes. It's essential for those with heart problems.
Read More
Frequently Asked Questions
9
Improved blood circulation
895 people found this helpful
I take nattokinase for blood thinning. Blood tests showed aggregation of erythrocytes and platelets, but after a month of use, there was significant improvement. I experienced heaviness in my head and legs, which gradually subsided. All tests returned to normal.
9
Reduced blood thickness
394 people found this helpful
My father had thick blood due to high cholesterol and developed diabetes post-Covid. After trying various blood thinning medications, I ordered him this highly rated nattokinase. Within a month, his blood became much thinner and his blood pressure began to normalise. He is very pleased with the results.
9
Normalised blood pressure
91 people found this helpful
After experiencing increased blood pressure, I took nattokinase for two months, and it returned to normal. It’s best to take it in the morning on an empty stomach, 30 minutes before breakfast. I recommend it to anyone suffering from coronavirus effects or at risk of thrombosis. Wishing good health to all!
9
Effective pressure regulator
213 people found this helpful
Nattokinase normalised my blood pressure significantly. After experiencing side effects from chemical drugs, I sought alternatives and found great results with nattokinase. My pressure dropped by 20-30 units after the first dose.
9
Enhanced blood flow
166 people found this helpful
I take Nattokinase daily for blood thinning. Initially, taking several capsules improved my circulation significantly but caused sleeplessness. In cold weather, I feel warmer. It's a powerful fibrinolytic enzyme, benefiting various ailments, and is safer and more effective than aspirin, causing no known allergic reactions in over 20 years.
9
Pain relief
142 people found this helpful
I'm currently taking nattokinase. After coronavirus, my legs hurt and swelled, but after more than a month of use, the pain and swelling have gone. It's unfortunate that I didn't know about this product sooner!
9
Effective aspirin alternative
188 people found this helpful
Nattokinase is a great alternative to aspirin. Having taken various blood thinners previously, I discovered nattokinase and its benefits. It supports heart health, aids in reducing cholesterol, and has numerous positive effects on the body. I highly recommend it as a substitute for aspirin.
9
Improved heart health
180 people found this helpful
Nattokinase has supported me for two years after transitioning from Xarelto. This natural solution, effective for blood clot removal and maintaining clear blood vessels, has eliminated my arrhythmia issues, greatly benefiting my heart health at a reasonable price.
0
Thin blood concerns
86 people found this helpful
I started taking nattokinase for a genetic tendency towards DVTs and heavy menstruation. Within two weeks, my veins became more pronounced, and I bruised easily. I am stopping the product as I believe it excessively thinned my blood, causing these issues.
9
We explored the effectiveness of a novel treatment combining nattokinase with magnetic vortex nanorobots for tackling blood clots. The study cleverly used these tiny robots, which are about 70 nanometers in size, powered by dual-frequency magnetic fields to improve drug delivery and enhance the effects of nattokinase.
By assembling into chain-like formations, these nanorobots can navigate through microvascular systems and directly target clots, creating mechanical forces to disrupt them efficiently. The combination of a low-frequency rotating field and a high-frequency alternating field helped not only to penetrate the thrombus but also to release nattokinase effectively.
Our findings revealed that this innovative approach, termed dual frequency-regulated magnetothrombolysis, achieved an impressive vasculature recanalization rate of 81.0% in thrombotic mice. This suggests that enhancing the therapeutic qualities of nattokinase with advanced nanotechnology represents a promising pathway for resolving blood clots more effectively.
By assembling into chain-like formations, these nanorobots can navigate through microvascular systems and directly target clots, creating mechanical forces to disrupt them efficiently. The combination of a low-frequency rotating field and a high-frequency alternating field helped not only to penetrate the thrombus but also to release nattokinase effectively.
Our findings revealed that this innovative approach, termed dual frequency-regulated magnetothrombolysis, achieved an impressive vasculature recanalization rate of 81.0% in thrombotic mice. This suggests that enhancing the therapeutic qualities of nattokinase with advanced nanotechnology represents a promising pathway for resolving blood clots more effectively.
8
We evaluated the potential of nattokinase, a natural enzyme known for breaking down blood clots, in treating patients with vascular diseases such as deep vein thrombosis and venous insufficiency. Our study involved 153 patients who were given a daily dose of 100 mg of nattokinase, either alone or alongside standard anticoagulants.
The results showed that nattokinase improved clinical symptoms significantly without causing any adverse reactions or drug interactions. We observed that while other treatments were included, nattokinase still played a crucial role in enhancing the patients' conditions. Moreover, throughout the follow-up period, there were no new cases of vascular diseases reported.
This study underscores the importance of monitoring patient progress and adjusting treatments as necessary while administering fibrinolytic medications. Ultimately, we can conclude that nattokinase offers a promising and safe option for both preventing and treating vascular diseases.
The results showed that nattokinase improved clinical symptoms significantly without causing any adverse reactions or drug interactions. We observed that while other treatments were included, nattokinase still played a crucial role in enhancing the patients' conditions. Moreover, throughout the follow-up period, there were no new cases of vascular diseases reported.
This study underscores the importance of monitoring patient progress and adjusting treatments as necessary while administering fibrinolytic medications. Ultimately, we can conclude that nattokinase offers a promising and safe option for both preventing and treating vascular diseases.
7
Nattokinase and unsaturated fats enhance fibrinolysis
We explored how certain foods may improve the blood-clot-dissolving effects of nattokinase, a powerful enzyme. Our findings highlighted that unsaturated fatty acids, particularly linoleic acid from red pepper, significantly boosted nattokinase's ability to break down fibrin, a key component in blood clots.
While unsaturated fats enhanced this process, saturated fats actually inhibited it. These insights suggest that incorporating nattokinase-rich foods like natto, along with oils rich in unsaturated fats, might offer cardiovascular advantages.
While unsaturated fats enhanced this process, saturated fats actually inhibited it. These insights suggest that incorporating nattokinase-rich foods like natto, along with oils rich in unsaturated fats, might offer cardiovascular advantages.
7
Nattokinase aids blood clot prevention
We aimed to understand how nattokinase, a powerful serine protease, can help prevent blood clots through its absorption and transport in the intestines. In our study, we tested different doses of nattokinase on mice to see how effectively it could prevent thrombosis induced by carrageenan. We used doses of 4000, 8000, and 12000 Fibrin Units per kilogram to evaluate the impacts on blood clot prevention.
Following this, we delved into how nattokinase is absorbed in the small intestine using various methods, including animal models, gut sac models, and Caco-2 cell monolayer models. Our findings suggested that nattokinase is moderately absorbed in the intestine, and this absorption relies on energy and time. By employing agents like chlorpromazine, nystatin, and EIPA, we observed that the internalization of nattokinase involves several pathways, including macropinocytosis and clathrin-mediated and caveolae-mediated endocytosis.
Overall, the results offer valuable insights into how oral supplementation of nattokinase could work inside our bodies to prevent blood clots, laying the groundwork for further research in this area.
Following this, we delved into how nattokinase is absorbed in the small intestine using various methods, including animal models, gut sac models, and Caco-2 cell monolayer models. Our findings suggested that nattokinase is moderately absorbed in the intestine, and this absorption relies on energy and time. By employing agents like chlorpromazine, nystatin, and EIPA, we observed that the internalization of nattokinase involves several pathways, including macropinocytosis and clathrin-mediated and caveolae-mediated endocytosis.
Overall, the results offer valuable insights into how oral supplementation of nattokinase could work inside our bodies to prevent blood clots, laying the groundwork for further research in this area.
References
- Zhang Z, Gao F, Mao J, Liu J, Zeng Z, et al. Biophysiochemically favorable, antithrombotic and pro-endothelial coordination compound nanocoating of copper (II) with protocatechuic acid & nattokinase on flow-diverting stents. Colloids Surf B Biointerfaces. 2025;249:114509. doi:10.1016/j.colsurfb.2025.114509
- Shi Y, Liu C, Gui Y, Guo Y, Zhang Y, et al. A Nattokinase-Loaded Nanozyme for Alleviating Acute Myocardial Infarction via Thrombolysis and Antioxidation. Adv Healthc Mater. 2024. doi:10.1002/adhm.202402763
- Gao R, Zhang W, Chen X, Shen J, Qin Y, et al. Dual Frequency-Regulated Magnetic Vortex Nanorobots Empower Nattokinase for Focalized Microvascular Thrombolysis. ACS Nano. 2024;18:29492. doi:10.1021/acsnano.4c04331
- Wang D, Kou Y, Guo T, Duan L, Chen J, et al. Intravenous injection of nattokinase-heparin electrostatic complex improves the therapeutic effect of advanced tumors by dissolving cancer-related thrombosis. Life Sci. 2024;355:122935. doi:10.1016/j.lfs.2024.122935
- Coutinho SB, Shirodkar RR, Kanjirakkandy A, Arulmozhi V, Vaithilingam M, et al. Production of Nattokinase from MRS18: A Bacterial Strain Isolated from Fermented Beans. Cardiovasc Hematol Agents Med Chem. 2024;22:223. doi:10.2174/0118715257275639231219054353
- Feng H, Liu C, Liu Q, Wang J, Zeng Y, et al. Study on the transport and internalisation mechanism of dietary supplement nattokinase in the small intestine using animal and Caco-2 cell monolayer models. Xenobiotica. 2023;53:670. doi:10.1080/00498254.2023.2284249
- Xia Y, Chen R, Ke Y, Han Q, Ma Z, et al. ROS-responsive phenylboronic ester-based nanovesicles as multifunctional drug delivery systems for the treatment of inflammatory and thrombotic complications. Biomater Sci. 2023;11:7805. doi:10.1039/d3bm01427d
- Li Y, Chen L, Tang X, Zhu W, Ma A, et al. Combined Computer-Aided Predictors to Improve the Thermostability of Nattokinase. Foods. 2023;12. doi:10.3390/foods12163045
- Modi A, Raval I, Doshi P, Joshi M, Joshi C, et al. Heterologous expression of recombinant nattokinase in Escherichia coli BL21(DE3) and media optimization for overproduction of nattokinase using RSM. Protein Expr Purif. 2023;203:106198. doi:10.1016/j.pep.2022.106198
- Wang Y, Wang H, Zhang Y, Xu F, Wang J, et al. Stepwise Strategy to Identify Thrombin as a Hydrolytic Substrate for Nattokinase. J Chem Inf Model. 2022;62:5780. doi:10.1021/acs.jcim.2c00978
- Pinontoan R, Sanjaya A, Jo J. Fibrinolytic characteristics of G8 isolated from natto. Biosci Microbiota Food Health. 2021;40:144. doi:10.12938/bmfh.2020-071
- Zhang X, Tong Y, Wang J, Lyu X, Yang R. Screening of a Bacillus subtilis strain producing both nattokinase and milk-clotting enzyme and its application in fermented milk with thrombolytic activity. J Dairy Sci. 2021;104:9437. doi:10.3168/jds.2020-19756
- Gallelli G, Di Mizio G, Palleria C, Siniscalchi A, Rubino P, et al. Data Recorded in Real Life Support the Safety of Nattokinase in Patients with Vascular Diseases. Nutrients. 2021;13. doi:10.3390/nu13062031
- Liu S, Zhu J, Liu C, Li J, Li Z, et al. Synthesis of sustained release/controlled release nanoparticles carrying nattokinase and their application in thrombolysis. Pharmazie. 2021;76:145. doi:10.1691/ph.2021.0155
- Li X, Yang X, Umar M, Zhang Z, Luo W, et al. Expression of a novel dual-functional polypeptide and its pharmacological action research. Life Sci. 2021;267:118890. doi:10.1016/j.lfs.2020.118890
- Zhang X, Lyu X, Tong Y, Wang J, Ye J, et al. Chitosan/casein based microparticles with a bilayer shell-core structure for oral delivery of nattokinase. Food Funct. 2020;11:10799. doi:10.1039/d0fo02349c
- Liu M, Xu Z, Wang Z, Wang D, Yang M, et al. Lipid-lowering, antihypertensive, and antithrombotic effects of nattokinase combined with red yeast rice in patients with stable coronary artery disease: a randomized, double-blinded, placebo-controlled trial. Front Nutr. 2024;11:1380727. doi:10.3389/fnut.2024.1380727
- Takagaki S, Suzuki M, Suzuki E, Hasumi K. Unsaturated fatty acids enhance the fibrinolytic activity of subtilisin NAT (nattokinase). J Food Biochem. 2020;44:e13326. doi:10.1111/jfbc.13326
